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Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England
A compararison of the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and the ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines against infection and COVID-19 disease in health and social care workers.
Status: Published
Categories
- OpenSAFELY
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Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England
This paper investigates the representativeness of OpenSAFELY-TPP data by comparing it to national population estimates.
Status: Published
Categories
- OpenSAFELY
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Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England
This paper describes the characters of individuals who have experienced COVID-19 vaccine breakthrough after their second vaccination.
Status: Published
Categories
- OpenSAFELY
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Association between oral anticoagulants and COVID-19-related outcomes
This paper investigates the association between OACs and COVID-19 outcomes in those with atrial fibrillation and a CHA2DS2-VASc score of 2.
Status: Published
Categories
- OpenSAFELY
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Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records
This paper combines results from longitudinal cohort studies with electronic health data from OpenSAFELY, to describe how risk of long COVID varies amongst demographic and clinical factors.
Status: Published
Categories
- OpenSAFELY
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Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies
This paper aimed to assess the risk of severe COVID-19 in adults with immune-mediated inflammatory diseases and in those on immune-modifying therapies.
Status: Published
Categories
- OpenSAFELY
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Effectiveness of BNT162b2 booster doses in England
We estimate the effectiveness of boosting with BNT162b2 compared with no boosting in eligible adults who had received two primary course vaccine doses in England.
Status: Preprint
Categories
- OpenSAFELY
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Safety of COVID-19 vaccination and acute neurological events
This paper investigates the potential association of COVID-19 vaccination with three acute neurological events: Guillain-Barré syndrome (GBS), transverse myelitis and Bell’s palsy.
Status: Published
Categories
- OpenSAFELY
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Impact of First UK COVID-19 Lockdown on Hospital Admissions
This study used OpenSAFELY (on behalf of NHS England), EAVEII (Scotland) and SAIL Databank (Wales) to investigate the weekly hospital admission rates for cancer, cardiovascular and respiratory conditions (excluding COVID-19) broken down by disease, sex, socioeconomic group and ethnicity group in a federated analysis across England, Scotland and Wales.
Status: Published
Categories
- OpenSAFELY
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Accident and emergency (AE) attendance in England following infection with SARS-CoV-2 Omicron or Delta
We estimate the risk of accident and emergency (AE) attendance following confirmation of SARS-CoV-2 infection in England, comparing infection with Omicron to Delta
Status: Preprint
Categories
- OpenSAFELY
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Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19 in England
Patients with COVID-19 are thought to be at higher risk of cardiometabolic and pulmonary complications, but quantification of that risk is limited. Working on behalf of NHS England, this study aimed to describe the overall burden of these complications in survivors of severe COVID-19 using OpenSAFELY.
Status: Published
Categories
- OpenSAFELY
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Comparison of methods for predicting COVID-19-related death in the general population using the OpenSAFELY platform
This paper evaluate different methods for predicting COVID-19-related death using the OpenSAFELY platform
Status: Published
Categories
- OpenSAFELY
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Potentially inappropriate prescribing of DOACs to people with mechanical heart valves
We conducted a retrospective cohort study of DOAC prescribing in people with a record of a mechanical heart valve between September 2019 and May 2021, and describe the characteristics of this population.
Status: Published
Categories
- OpenSAFELY
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Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation
This paper investigates whether risks of hospital admission and death, overall and by specific cause, are raised following discharge from a COVID-19 hospitalisation.
Status: Published
Categories
- OpenSAFELY
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Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic
This paper describe trends in the mortality risk among residents of care homes compared to private homes during the first and second waves of the COVID-19 pandemic in England.
Status: Published
Categories
- OpenSAFELY
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OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19
Working on behalf of NHS England, this study used the OpenSAFELY platform to describe the volume and variation of coded clinical activity in general practice between January 2019 and September 2020, taking respiratory disease and laboratory procedures as examples.
Status: Published
Categories
- OpenSAFELY
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Trends and clinical characteristics of COVID-19 vaccine recipients
Vaccine coverage and time trends across a range of demographic and fine-grained clinical subgroups in eight Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts.
Status: Published
Categories
- OpenSAFELY
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Impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic
This paper describes which people were switched from warfarin to DOACs during the COVID-19 pandemic following an update in national guidance
Status: Published
Categories
- OpenSAFELY
