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Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022
This study aimed to describe the burden of COVID-19-related mortality in population subgroups and how this has changed over successive waves of the pandemic, and report trends in absolute and relative COVID-19-related mortality risks across clinical and demographic population subgroups from 2020 to 2022.
Status: Published
Categories
- OpenSAFELY
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Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
Data-driven approaches have the potential to overcome existing biases with regard to the planning and execution of audits, interventions, and policy making within NHS organizations, potentially revealing new targets for improved health care service delivery.
Categories
- OpenPrescribing
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Deaths at home during the Covid-19 pandemic and implications for patients and services
A comparison of the services used by people who died at home in England in the first year of the pandemic to the year prior to the pandemic, exploring indicators of quality of care, and looking at differences between sociodemographic groups.
Status: Published
Categories
- OpenSAFELY
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Postoperative mortality and complications in patients with and without pre-operative SARS-CoV-2 infection
We adapted the COVIDSurg protocol for a service evaluation of surgical procedures that took place within the English NHS from 17 March 2018 to 17 March 2022.
Status: Published
Categories
- OpenSAFELY
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Comparative effectiveness of BNT162b2 versus mRNA-1273 covid-19 vaccine boosting in England
A comparison of the Pfizer and Moderna vaccines for protecting against Covid-19 during the first booster programme in England
Status: Published
Categories
- OpenSAFELY
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First dose COVID-19 vaccine coverage amongst adolescents and children in England
Describing trends and variation in first dose COVID vaccine coverage in different clinical and demographic groups amongst adolescents and children in England
Status: Published
Categories
- OpenSAFELY
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Trends, variation, and clinical characteristics of recipients of antiviral drugs and neutralising monoclonal antibodies for covid-19 in community settings
This paper aims to develop a framework for detailed near real-time monitoring of treatment deployment, to ascertain eligibility status for patients and to describe trends and variation in coverage of treatment between geographic, clinical and demographic groups.
Status: Published
Categories
- OpenSAFELY
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OpenSAFELY NHS Service Restoration Observatory 2
We describe changes in the volume and variation of coded clinical activity in general practice in: (i) cardiovascular disease, (ii) diabetes, (iii) mental health, (iv) female and reproductive health, (v) screening, and (vi) processes related to medication.
Status: Published
Categories
- OpenSAFELY
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Factors associated with COVID-19 vaccine uptake in people with kidney disease
We describe COVID-19 vaccine coverage among people with moderate-to-severe kidney disease in England up to 31 August 2022, and characterise individual-level factors associated with delayed vaccine uptake.
Status: Published
Categories
- OpenSAFELY
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Primary care coding activity related to the use of online consultation systems or remote consulting
We explore general practice coding activity associated with the use of online consultation systems in terms of trends, COVID-19 effect, variation and quality.
Status: Preprint
Categories
- OpenSAFELY
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Challenges in estimating waning effectiveness of two doses of BNT162b2 and ChAdOx1 COVID-19 vaccines beyond six months
Quantifying the waning effectiveness of second COVID-19 vaccination beyond six months and against the omicron variant
Status: Preprint
Categories
- OpenSAFELY
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Identifying Patterns of Clinical Interest in Clinicians' Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review
A new method for prioritizing prescribing outliers for clinical review with discussion of two illustrative examples of anti-psychotics
Categories
- OpenPrescribing
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Comparative effectiveness of two- and three-dose schedules involving AZD1222 and BNT162b2 in people with kidney disease
We compared the risk of COVID-19 among people with moderate-severe kidney disease who received different combinations of Astrazeneca and Pfizer–BioNTech COVID-19 vaccine over the course of the pandemic
Status: Preprint
Categories
- OpenSAFELY
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Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community
Comparing the effectiveness of sotrovimab (a neutralising monoclonal antibody) with molnupiravir (an antiviral) in preventing severe outcomes of covid-19 in adult patients infected with SARS-CoV-2 in the community and at high risk of severe outcomes from covid-19.
Status: Published
Categories
- OpenSAFELY
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Incidence and management of inflammatory arthritis in England before and during the COVID-19 pandemic
We used OpenSAFELY to replicate key metrics from the National Early Inflammatory Arthritis Audit (NEIAA), and to assess the impact of COVID-19 on the delivery of care for people with autoimmune inflammatory arthritis in England.
Status: Published
Categories
- OpenSAFELY
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Recording of ‘COVID-19 vaccine declined’
A description of the patterns of usage of codes for COVID-19 vaccines being declined.
Status: Published
Categories
- OpenSAFELY
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Association between household composition and severe COVID-19 outcomes in older people by ethnicity
This paper aims to quantify the association between household composition and risk of severe COVID-19 by ethnicity for older individuals
Status: Published
Categories
- OpenSAFELY
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Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose
A cohort study to assess the extent of waning of effectiveness following a second dose of BNT162b2 and ChAdOx1 covid-19 vaccines
Status: Published
Categories
- OpenSAFELY
