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The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England
We studied how antibiotic precribing for common infections in primary changed duding the Covid-19 pandemic and how this may have affected clincial outcomes
Status: Published
Categories
- OpenSAFELY
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Impact of the COVID-19 pandemic on antipsychotic prescribing in individuals with autism, dementia, learning disability, serious mental illness or living in a care home
We describe the impact of the the COVID-19 pandemic on antipsychotic prescribing in those with autism, dementia, learning disability, serious mental illness or living in a care home.
Status: Published
Categories
- OpenSAFELY
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Fit notes associated with COVID-19 in 24 million patients’ primary care records
This study quantified the fit note rate in people with documented SARS-CoV-2 infection or COVID-19 diagnosis in 2020, 2021 and 2022 overall, by demographics, and by time since diagnosis. We also used adjusted Cox regression to compare the fit note rate to the general population.
Status: Preprint
Categories
- OpenSAFELY
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Effect of the 2022 COVID-19 booster vaccination campaign in 50 year olds in England
This study evaluated the effectiveness of the 2022 autumn COVID-19 booster campaign in 50 year olds in England using a regression discontinuity design.
Status: Preprint
Categories
- OpenSAFELY
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Challenges in Estimating the Effectiveness of 2 Doses of COVID-19 Vaccine Beyond 6 Months in England
This paper discusses the challenges in estimating long-term (>6 months) vaccine effectiveness in observational data, primarily due to high uptake of a subsequent third vaccine dose.
Status: Published
Categories
- OpenSAFELY
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Impact of COVID-19 on recorded blood pressure screening and hypertension management in England
We describe the impact of the COVID-19 pandemic on blood pressure screening and hypertension management.
Status: Preprint
Categories
- OpenSAFELY
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Eleven key measures for monitoring general practice clinical activity during COVID-19
This paper presents an important effort to develop an open-source software framework for monitoring trends and variations in healthcare over time in England. They demonstrate a compelling example of how this system can track key healthcare indicators over the course of the COVID-19 pandemic.
Status: Published
Categories
- OpenSAFELY
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Evaluation of the impact of COVID-19 pandemic on hospital admission related to common infections
We studied the changes in hospital admission rates for common infections during the Covid-19 pandemic, for those having and having not received antibiotic prescriptions in primary care
Status: Preprint
Categories
- OpenSAFELY
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Repeated antibiotic exposure and risk of hospitalisation and death following COVID-19 infection
We examined whether prior frequent antibiotic exposure is associated with severe COVID-19 outcomes.
Status: Published
Categories
- OpenSAFELY
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Data-driven identification of potentially successful intervention implementations: a proof of concept using five years of opioid prescribing data from over 7000 practices in England
By applying one of our existing analysis tools to a national dataset, we were able to rank NHS organisations by reduction in opioid prescribing rates. Highly ranked organisations are candidates for further qualitative research into intervention design and implementation.
Status: Preprint
Categories
- OpenPrescribing
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Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England
We aimed to describe the impact of pandemic-related disruption on ethnic differences in clinical monitoring and hospital admissions for non-COVID conditions in England.
Status: Published
Categories
- OpenSAFELY
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Patient Characteristics Associated with Repeat Antibiotic Prescribing Pre- and during the COVID-19 Pandemic
With the approval of NHS England, we conducted a retrospective cohort study of >19 million English primary care patient records using the OpenSAFELY-TPP analytics platform. We analysed repeat/non-repeat prescribing frequency in monthly patient cohorts between January 2020 and 2022.
Status: Published
Categories
- OpenSAFELY
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A National Audit of Pancreatic Enzyme Prescribing in Pancreatic Cancer from 2015 to 2023 in England
Investigating the impact of the COVID-19 pandemic on PERT prescribing to people with unresectable pancreatic cancer and to investigate the national and regional rates from January 2015 to January 2023.
Status: Published
Categories
- OpenSAFELY
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Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY
This study aimed to implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing.
Status: Published
Categories
- OpenSAFELY
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Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages
We used the OpenSAFELY platform to emulate target trials to estimate the effectiveness of sotrovimab or molnupiravir, versus no treatment.
Status: Preprint
Categories
- OpenSAFELY
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Impact of COVID-19 on broad-spectrum antibiotic prescribing for common infections in primary care in England
The COVID-19 pandemic impacted the healthcare systems, adding extra pressure to reduce antimicrobial resistance. Therefore, we aimed to evaluate changes in antibiotic prescription patterns after COVID-19 started.
Status: Published
Categories
- OpenSAFELY
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The impact of COVID-19 on antibiotic prescribing in primary care in England
This study predicted risk factors for potentially inappropriate prescribing in primary care and how this changed during the Covid-19 pandemic
Status: Published
Categories
- OpenSAFELY
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Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data
This paper discusses the challenges in estimating vaccine effectiveness using observational data, and describes two approaches that help to overcome these challenges.
Status: Published
Categories
- OpenSAFELY
