1. Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England: a matched cohort study in OpenSAFELY-TPP

    A comparison of the Pfizer BA.4-5 and Sanofi vaccines for protecting against Covid-19 during Spring 2023 booster programme in England

    Status
    Preprint

    Categories

    • OpenSAFELY
  2. Changes in opioid prescribing during the COVID-19 pandemic in England: cohort study of 20 million patients in OpenSAFELY-TPP

    This study described changes in prevalent and new opioid prescribing during the COVID-19 pandemic, overall, among people in care homes, and stratified by demographics.

    Status
    Preprint

    Categories

    • OpenSAFELY
  3. OpenSAFELY: Measuring BMI in 22 million patients in England

    This study describes the use of four derivations of BMI in OpenSAFELY.

    Categories

    • OpenSAFELY
  4. OpenSAFELY: a platform for analysing electronic health records designed for reproducible research

    This paper describes OpenSAFELY's reproducibility-by-design approach in detail.

    Status
    Preprint

    Categories

    • OpenSAFELY
  5. Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic: a cohort study of 23.5 million people in England

    We determine whether periods of disruption were associated with increased ‘avoidable’ hospital admissions and wider social inequalities in England.

    Categories

    • OpenSAFELY
  6. Educational interventions delivered to prescribing advisers to influence primary care prescribing: a very low-cost pragmatic randomised trial using routine data from OpenPrescribing.net

    A low cost randomised trial of an educational intervention in CCGs to influence prescribing of low-priority items

    Status
    Preprint

    Categories

    • OpenPrescribing
  7. Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY

    We describe the completeness and consistency of primary care ethnicity recording in the OpenSAFELY-TPP database, containing linked primary care and hospital records in >25 million patients in England. We also compared the ethnic breakdown in OpenSAFELY-TPP with that of the 2021 UK census.

    Status
    Preprint

    Categories

    • OpenSAFELY
  8. Clinical and health inequality risk factors for non-COVID-related sepsis during the global COVID-19 pandemic: a national case-control and cohort study

    We used OpenSAFELY-TPP data to elucidate the association between non-Covid-19 related sepsis and a range of risk factors during the Covid-19 pandemic

    Categories

    • OpenSAFELY
  9. Interpreting Pathology Test Result Values With Comparators (<, >) in Electronic Health Records research: an OpenSAFELY short data report

    A short data report about comparators in pathology test results

    Status
    Preprint

    Categories

    • OpenSAFELY
  10. Antibiotics for Common Infections in Primary Care Before, During and after the COVID-19 Pandemic and Extent of Risk-Based Prescribing: Need for Personalised Guidelines

    We assessed the changes in risk-based prescribing behaviours of antibiotics for common infections in primary care during the Covid-19 pandemic

    Status
    Preprint

    Categories

    • OpenSAFELY
  11. Group A streptococcal cases and treatments during the COVID-19 pandemic and 2022 outbreak: a retrospective cohort study in England using OpenSAFELY-TPP

    This study described the impact of the COVID-19 pandemic on Group A streptococcal (GAS) cases and related antibiotic prescriptions.

    Status
    Preprint

    Categories

    • OpenSAFELY
  12. The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England

    We studied how antibiotic precribing for common infections in primary changed duding the Covid-19 pandemic and how this may have affected clincial outcomes

    Categories

    • OpenSAFELY
  13. Effect of the 2022 COVID-19 booster vaccination campaign in 50 year olds in England: regression discontinuity analysis in OpenSAFELY

    This study evaluated the effectiveness of the 2022 autumn COVID-19 booster in 50 year olds

    Status
    Preprint

    Categories

    • OpenSAFELY
  14. Challenges in Estimating the Effectiveness of 2 Doses of COVID-19 Vaccine Beyond 6 Months in England

    This paper discusses the challenges in estimating long-term (>6 months) vaccine effectiveness in observational data, primarily due to high uptake of a subsequent third vaccine dose.

    Categories

    • OpenSAFELY
  15. Fit notes associated with COVID-19 in 24 million patients’ primary care records: A cohort study in OpenSAFELY-TPP.

    This study comprehensively quantified the fit note rate in people with COVID-19 in 2020, 2021 and 2022.

    Status
    Preprint

    Categories

    • OpenSAFELY
  16. The impact of COVID-19 on medication reviews in English primary care. An OpenSAFELY-TPP analysis of 20 million adult electronic health records.

    This study investigated whether the rate of medication reviews in primary care were affected during the COVID-19 pandemic, with breakdown by regional, clinical and demographic subgroups.

    Status
    Preprint

    Categories

    • OpenSAFELY
  17. The impact of the COVID-19 pandemic on Antipsychotic Prescribing

    We describe the impact of the the COVID-19 pandemic on antipsychotic prescribing in those with autism, dementia, learning disability, serious mental illness or living in a care home.

    Categories

    • OpenSAFELY
  18. Impact of COVID-19 on recorded blood pressure screening and hypertension management in England: An analysis of monthly changes in Quality and Outcomes Framework indicators in OpenSAFELY

    We describe the impact of the COVID-19 pandemic on blood pressure screening and hypertension management

    Status
    Preprint

    Categories

    • OpenSAFELY