Papers
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The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate
This study investigated whether disease-modifying anti-rheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic, with additional focus on effects within key health inequality groups.
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- Published
Categories
- OpenSAFELY
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The impact of COVID-19 on medication reviews in English primary care
This study investigated whether the rate of medication reviews in primary care were affected during the COVID-19 pandemic, with breakdown by regional, clinical and demographic subgroups.
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- Published
Categories
- OpenSAFELY
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Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England
A comparison of the Pfizer BA.4-5 and Sanofi vaccines for protecting against Covid-19 during Spring 2023 booster programme in England
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- Preprint
Categories
- OpenSAFELY
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Changes in opioid prescribing during the COVID-19 pandemic in England
This study described changes in prevalent and new opioid prescribing during the COVID-19 pandemic, overall, among people in care homes, and stratified by demographics.
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- Preprint
Categories
- OpenSAFELY
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Measuring BMI in 22 million patients in England
This study describes the use of four derivations of BMI in OpenSAFELY.
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- Published
Categories
- OpenSAFELY
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Safety of direct-acting oral anticoagulant (DOAC) prescribing
This study aimed to identify the proportion of those prescribed a DOAC with recorded: weight, estimated Glomerular Filtration Rate (eGFR), creatinine, creatinine clearance (CrCl) and atrial fibrillation (AF). In those with recorded AF and CrCl prescribed the study aimed to identify the proportion with a recommended DOAC dose.
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- Published
Categories
- OpenSAFELY
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OpenSAFELY: a platform for analysing electronic health records designed for reproducible research
This paper describes OpenSAFELY's reproducibility-by-design approach in detail.
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- Preprint
Categories
- OpenSAFELY
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Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic
We determine whether periods of disruption were associated with increased ‘avoidable’ hospital admissions and wider social inequalities in England.
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- Published
Categories
- OpenSAFELY
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Educational interventions delivered to prescribing advisers to influence primary care prescribing: a very low-cost pragmatic randomised trial using routine data from OpenPrescribing.net
A low cost randomised trial of an educational intervention in CCGs to influence prescribing of low-priority items
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- Preprint
Categories
- OpenPrescribing
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Ursodeoxycholic acid and severe COVID-19 outcomes in people with liver disease
Cohort study investigating whether ursodeoxycholic acid was associated with COVID-19 related hospitalisation and death in people with primary biliary cirrhosis and primary sclerosing cholangitis.
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- Preprint
Categories
- OpenSAFELY
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Impact of COVID-19 on mental illness in vaccinated and unvaccinated people
This study examined associations of COVID-19 with subsequent mental illness in the pre-vaccination period of the pandemic and for unvaccinated and vaccinated people after vaccination became available.
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- Preprint
Categories
- OpenSAFELY
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Clinical and health inequality risk factors for non-COVID-related sepsis during the global COVID-19 pandemic
We used OpenSAFELY-TPP data to elucidate the association between non-Covid-19 related sepsis and a range of risk factors during the Covid-19 pandemic
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- Published
Categories
- OpenSAFELY
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Consistency, completeness and external validity of ethnicity recording in NHS primary care records
We describe the completeness and consistency of primary care ethnicity recording in the OpenSAFELY-TPP database, containing linked primary care and hospital records in >25 million patients in England. We also compared the ethnic breakdown in OpenSAFELY-TPP with that of the 2021 UK census.
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- Preprint
Categories
- OpenSAFELY
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Interpreting pathology test result values with comparators (<, >) in Electronic Health Records research
A short data report about comparators in pathology test results
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- Published
Categories
- OpenSAFELY
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Antibiotics for Common Infections in Primary Care Before, During and after the COVID-19 Pandemic and Extent of Risk-Based Prescribing: Need for Personalised Guidelines
We assessed the changes in risk-based prescribing behaviours of antibiotics for common infections in primary care during the Covid-19 pandemic
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- Preprint
Categories
- OpenSAFELY
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Group A streptococcal cases and treatments during the COVID-19 pandemic and 2022 outbreak
This study described the impact of the COVID-19 pandemic on Group A streptococcal (GAS) cases and related antibiotic prescriptions.
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- Preprint
Categories
- OpenSAFELY
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The impact of COVID-19 on medication reviews in English primary care
This study investigated whether the rate of medication reviews in primary care were affected during the COVID-19 pandemic, with breakdown by regional, clinical and demographic subgroups.
- Status
- Preprint
Categories
- OpenSAFELY
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The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England
We studied how antibiotic precribing for common infections in primary changed duding the Covid-19 pandemic and how this may have affected clincial outcomes
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- Published
Categories
- OpenSAFELY